Robert H. Adams, former United States Senator from Mississippi.
William Wirt Adams, Confederate Army officer, grew up in Natchez.
Lynda Lee Mead was crowned Miss Mississippi in 1959 and Miss America in 1960. A Natchez city street, Lynda Lee Drive, is named in her honor.
It was the birthplace of country singer Mickey Gilley. Minnesota Vikings cornerback Cedric Griffin was born in Natchez, but was raised in San Antonio, Texas. University of Pittsburgh All-American defensive end Hugh Green was born in Natchez. Pro Football Hall of Famer Billy Shaw was born in Natchez. Novelist Greg Iles is a Natchez native. Glen Ballard, a five-time Grammy Award winning songwriter/producer Hound Dog Taylor, a blues singer and slide guitar player. Pierre Adolphe Rost, a member of the Mississippi Senate and was a commissioner to Europe for the Confederate States. Emigrated to Natchez from France.
Alexander O'Neal, R&B singer Nook Logan Baseball player for the Washington Nationals. Regarded as one of the fastest players in the majors. Anne Moody, Civil Rights activist and author of Coming of Age in Mississippi, attended Natchez Junior College. Dwayne Brown The leader of the South Natchez football and baseball teams in the late 60's. Now resides in Lafayette working for the city.